BAFF受体（B细胞活化因子受体，BAFF-R），也称为肿瘤坏死因子受体超家族成员13C（TNFRSF13C）或CD268抗原。B淋巴瘤细胞的增殖转移受BAFF信号通路的调节，而BAFF-R作为BAFF信号通路的关键信号分子，在B 淋巴瘤细胞的增殖中起重要作用^【1,2】。研究显示，BAFF-R 不仅表达于成熟的B 淋巴细胞，而且见于B 淋巴瘤细胞表面，在刺激B 淋巴瘤细胞增殖、避免B淋巴细胞凋亡等方面发挥重要作用，是研究相关疾病的重要潜在靶点^【3-5】。目前，针对BAFF-R的抗体药开发已经进入临床三期。

产品名：重组人源BAFFR蛋白

物种：人源

基因序列号：Q96RJ3

标签：Human-Fc Tag

标签位点：C端

酶切位点：肠激酶

表达区域：胞外段7-71AA

宿主细胞：CHO

纯度：＞90%

纯化方式：Protein A柱

保存体系：PBS+20%甘油

储存条件：-80℃

图示：左图Lane M为 protein MW marker，Lane 1为 15ug BAFFR-Fc蛋白；

右图为流式检测BAFFR-Fc蛋白与过表达 BAFFR-CAR的293T结合情况

参考资料：

1. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors

2. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

3. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

4. BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

5. Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL